Getting My ceesdekker To Work
Getting My ceesdekker To Work
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Halfway by his profession, Cees Dekker reinvented himself. Immediately after a long time of hardcore physics, he shifted his aim to ‘nanobiology’ with the turn on the millennium. A time period he coined himself, like a make any difference of truth.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters
We build stage-of-treatment diagnostics take a look at of neglected tropical conditions inside of resource-limited configurations, based upon Crspr/Cas9 detecting of pathogen’s DNA in human body fluids.
SMC complexes can pass physical roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the basic function of spatial confinement in the molecular and cellular level. Our projects include the following:
Studying DNA loop extrusion by SMC proteins for chromosome architecture https://www.ceesdekker.net with one-molecule assays.
The rotors harness energy from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient within the nanopore, which are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting methods to developing Strength-transducing motors at nanoscale interfaces.
It was for the duration of this era that Dekker completed investigate on magnetic spin systems and on noise in superconductors and semiconductors.
In 1993 he was appointed as Associate Professor at Delft College of Technological know-how. Inside the mid-nineteen nineties Dekker and his team attained achievements with the discovery in the Digital Attributes of carbon nanotubes, the very first solitary-molecule transistor and various nanoscience.
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes
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It was an incredibly attention-grabbing time, in the course of which I gained a lot of assist from Delft College of Technologies, the place I had been a professor at some time, and I started out various collaborations with molecular biologists. That served me discover a whole lot.’